| 13:00 – 14:30 | Panel I: MS Biomarkers Revisited: Imaging and fluid biomarkers and beyond in the era of new diagnostic criteria Chairs: Murat Terzi, M. Ufuk Aluçlu |
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| Panelists: Özlem Ethemoğlu, Atay Vural, Bilgin Öztürk, Sedat Şen, Mehmet Fatih Yetkin |
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| 14:30 – 15:15 | Satellite Symposium- Abdi İbrahim Chair: Hüsnü Efendi |
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| Dimetil Fumarat ve Teriflunomid Tedavisinde Güncel Veriler ve MS’te Engellilik Kavramına Bakış Serkan Demir, Mehmet Fatih Yetkin |
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| 15:15 - 15:30 | Break  |
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| 15:30 – 17:00 | Panel II: Managing MS: Current Treatment Options and Clinical Approaches Chairs: Ömer Faruk Turan, Egemen İdiman |
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| Panelists: Kadriye Ağan, Esra Gürsoy, Alev Leventoğlu, Semra Mungan, Cihat Uzunköprü, Destan Bünül |
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| 17:00-17:45 | Satellite Symposium- Sanovel Chairs: Ayşe Altıntaş, Özlem Ethemoğlu |
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| 17:00-17:45 | Speakers: Mesude Tütüncü, Rabia Gökçen Gözübatık Çelik |
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| 17:45-18:00 | Break |
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| 18:00-19:00 | Panel III: Young Investigators & European Charcot Foundation Fellowship Community Special Session Chairs: Meral Seferoğlu, Rabia Koç |
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| 18:00 – 18:05 | Welcome & Introduction Meral Seferoğlu, Rabia Koç |
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| 18:05 – 18:20 | The Role of ECF with Young Researchers in MS Marjan Steppe |
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| 18:20– 18:35 | Leadership & Innovation in MS Research: A Youth-Driven Approach Sara Samadzadeh |
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| 18:35 – 18:50 | Being an MS Master’s Student: Academic and Clinical Reflections Abdülkadir Tunç |
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| 18:50 – 19:00 | Panel Discussion / Q&A | ||
| 19:00-20:00 | Panel IV: Rehabilitation in MS Chairs: Aysun Ünal, Gürdal Orhan |
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| Panelist: Cognitive Rehabilitation: Serkan Özakbaş |
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| Panelist: Physical Rehabilitation: Mesrure Köseoğlu |
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| Panelist: Artificial Intelligence & Brain-Computer Interface: Tuncay Gündüz |
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| 20:00 – 20: 20 | Rational Drug Use Session Chair: Tahir Kurtuluş Yoldaş |
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| Panelist: Yaşar Altun |
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| 20:20-21:00 | Break & Buffet Dinner on site | ||
| 21:00-23:00 | Panel V: Diagnosing MS and Related Diseases – A Special Evening Event Chair: Sabahattin Saip |
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| Panelists: Münife Neyal, Özgül Ekmekçi, Sıla Usar, Burcu Altunrende, Haluk Gümüş Case Presentations: Gökçen Gözübatık Çelik, Ali Özhan Sıvacı, İpek Güngör Doğan, Pınar Acar Özen, Bedriye Karaman, Duygu Arslan Mehdiyev |
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| 08:00-09:00 | Poster Sessions | ||
| 09:00-09:15 | OFFICIAL OPENING & Presentation of the Istanbul MS days awards Chairs: Rana Karabudak, Husnu Efendi, Orhun H. Kantarci, Aksel Siva |
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| 09:00-09:15 | Opening address and a quick overview of the 10 years of Istanbul MS days Aksel Siva, Rana Karabudak, Orhun H. Kantarci, Husnu Efendi & Jack P. Antel |
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| 09:15-09:30 | Welcome address 1: The 45 years of MS in 15 minutes Aksel Siva |
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| 09:30-09:45 | Welcome address 2: Rumi: Between the absolutes of doing it wrong and right Orhun H. Kantarci |
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| 09:45-10:00 | Presentation of the Istanbul MS days award Aksel Siva, Rana Karabudak, Orhun H. Kantarci, Husnu Efendi |
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| 10:00-10:30 | Istanbul MS Days: Learning from our mistakes in defining diseases Brain G. Weinshenker |
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| 10:30-10:45 | Break |
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| 10:45-12:30 | SESSION-1: Learning from mistakes in science Discussants & Chairs: Frauke Zipp, Riadh Gouider, Cavit Boz |
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| 10:45-11:00 | Introduction to the session: "Opportunities lost by dismissing or trivializing negative findings in MS research?" Frauke Zipp |
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| 11:00-11:20 | Learning from Mistakes Janet Hafler |
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| 11:20-11:40 | Mistakes in the society Boris Zalc |
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| 11:40-12:00 | Pitfalls of genomic “big-data” Philip L. De Jager |
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| 12:00-12:30 | Q & A, Discussion | ||
| 12:30-13:30 | Lunch & In-Lunch Satellite Symposium - Farmanova Chair: Aksel Siva |
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| A New Era of B Cell Therapies: Ofatumumab Celia Oreja-Guevara |
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| 13:30-15:00 | SESSION-2: Microglia in MS Discussants & Chairs:Jack P. Antel, Samia Khoury, Erdem Tüzün |
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| 13:30-13:45 | Introduction to the session - The old friend or new foe: why did we ignore microglia all these years? Jack P. Antel |
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| 13:45-14:05 | Dynamic and changing roles of microglia in MS Bruce Trapp |
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| 14:05-14:25 | More questions than answers from BTK inhibitor research in MS Amit Bar-Or |
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| 14:25-14:45 | Molecular imaging is the answer - Why are you afraid of PET? Laura Airas |
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| 14:45-15:15 | Q & A, Discussion | ||
| 15:15-15:30 | Break |
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| 15:30-17:30 | SESSION-3: Modeling MS in the future Discussants & Chairs:Tanja Kuhlmann, Husnu Efendi, Magd Zakaria |
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| 15:30-15:45 | Introduction to the session: Rethinking Models of MS: Bridging the Gaps Between Pathology, Prediction, and Progress Tanja Kuhlmann |
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| 15:45-16:05 | Modeling MS pathology: Going beyond EAE Hans Lassmann |
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| 16:05-16:25 | Modeling the future of MS research: clinical clues that help or mislead Andrew Chan |
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| 16:25-16:45 | Modeling the future of MS research: MRI clues that help or mislead
Nicola De Stefano |
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| 16:45-17:15 | Q & A, Discussion | ||
| 17:15-17:30 | Break |
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| 17:30-19:15 | SESSION-4: Impact of hormones in neuroimmunology Discussants & Chairs: Sandra Vukusic, Ayşe Altıntaş, Gülşen Akman Demir |
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| 17:30-17:45 | Introduction to the session: Sex Matters in MS: Potential therapeutic inertia affecting treatment in women with MS compared to men Sandra Vukusic |
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| 17:45-18:05 | What might have been missed by not running sex-specific clinical trials in MS? Kerstin Hellwig |
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| 18:05-18:25 | Impact of sex hormone switches in neuroimmunology – MS and beyond Burcu Zeydan |
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| 18:25-18:45 | Impact of sex hormones on animal models of MS Manu Rangachari |
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| 18:45-19:15 | Q & A, Discussion | ||
| 19:30 | Opening Reception | ||
| 08:00-09:00 | Oral Abstract Presentations | ||
| 09:05-11:00 | SESSION - 5: Myelin gets sick early in MS Discussants & Chairs: Catherine Lubetzki, Aslı Tuncer, Murat Kürtüncü |
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| 09:05-09:20 | Introduction to the session- Myelin is not the only actor in MS Catherine Lubetzki |
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| 09:20-09:40 | More questions than answers in remyelination trials in MS Peter Calabresi |
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| 09:40-10:00 | Interactions between astrocytes and oligodendroglia in MS Daniel Reich |
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| 10:00-10:20 | PET as a single quantitative remyelination marker for clinical trials Bruno Stankoff |
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| 10:20-10:50 | Q & A, Discussion | ||
| 10:50-11:05 | Break |
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| 11:05-12:50 | SESSION - 6: Simplifying the clinical phenotype definitions of MS Discussants & Chairs: Andrew J. Solomon, Rana Karabudak, Refik Pul |
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| 11:05-11:20 | Introduction to the session: Has the new diagnostic criteria increased or decreased the risk of misdiagnosis in MS globally? Andrew J. Solomon |
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| 11:20-11:40 | Single agnostic definition of MS – the imaging-clinical continuum Orhun Kantarci |
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| 11:40-12:00 | Extremes of MS - Aggressive versus benign Ellen Mowry |
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| 12:00-12:20 | Separation of targets for differing trial endpoints – PIRA vs. RAW Daniel Ontaneda |
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| 12:20-12:50 | Q & A, Discussion | ||
| 12:50-13:50 | Lunch & In-Lunch Satellite Symposium - Roche Chair: Aslı Tuncer |
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| Timing of Ocrelizumab in MS: Clinical Impact and Efficacy of On Time Initiation Speaker: Angela Vidal Jordana |
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| 13:50-15:30 | SESSION-7: Defining MS phenotypes by biomarkers Discussants & Chairs: Eric Thouvenot, Jorge Correale, Ugur Uygunoglu |
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| 13:50-14:05 | Introduction to the session: From Missteps to Milestones: Rethinking Biomarkers in MS Phenotyping Eric Thouvenot |
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| 14:05-14:25 | Biomarkers of pre-symptomatic disease in MS – lessons from RIS Christine Lebrun-Frenay |
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| 14:25-14:45 | Pre- and post-symptomatic immunophenotypes of MS Heinz Wiendl |
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| 14:45-15:05 | Should AI care for our definitions of MS phenotypes? Vilas Menon |
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| 15:05-15:35 | Q & A, Discussion | ||
| 15:35-15:50 | Break |
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| 15:50-17:35 | SESSION-8: Risk factor mitigation in MS Discussants & Chairs: Nikolaos Grigoriadis, Eda Tahir Turanlı, Yeşim Beckman |
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| 15:50-16:05 | Introduction to the session: Mitigation Starts with Recognition: The Cost Of not addressing risk of MS Nikolaos Grigoriadis |
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| 16:05-16:25 | Lessons from our mistakes in epidemiology of MS Alberto Ascherio |
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| 16:25-16:45 | Is the gut the new solution for the brain? David Hafler |
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| 16:45-17:05 | EBV vaccination or microbiome transfer – which is the better path forward for MS prevention? Thomas Berger |
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| 17:05-17:35 | Q & A, Discussion | ||
| 17:35-17:50 | Break |
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| 17:50-19:35 | SESSION - 9: Larger than life clinical trials in MS Discussants & Chairs: Ludwig Kappos, Hans-Peter Hartung, Melih Tutuncu |
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| 17:50-18:05 | Introduction to the session: Decades of Experience in MS Therapeutic Trials: Key Lessons Learned Ludwig Kappos |
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| 18:05-18:25 | Give me the ideal clinical trial in MS - what is amiss in the past ones? Xavier Montalban |
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| 18:25-18:45 | Real value of harmonization of imaging for clinical trials Maria Pia Sormani |
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| 18:45-19:05 | Loosing specificity while looking for commonality and sensitivity in MS trials Jiwon Oh |
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| 19:05-19:35 | Q & A, Discussion | ||
| 20:00 | Leave for dinner | ||
| 08:00-08:45 | Morning Satellite Symposium - Alexion Chair: Ayşe Altıntaş |
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| Targeting the Source: Complement Blockade in NMOSD Jin Nakahara, Melih Tütüncü |
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| 08:45-10:15 | SESSION - 10: Don’t ignore cognition in MS Discussants & Chairs: Anat Achiron, Najib Kissani, Serkan Demir |
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| 08:45-08:55 | Introduction to the session: We protected the brain but lost the mind in MS! Anat Achiron |
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| 08:55-09:15 | Complex imaging signatures of cognitive decline in MS Korhan Buyukturkoglu |
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| 09:15-09:35 | Impact of ethnicity on cognition in MS Nabeela Nathoo |
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| 09:35-09:55 | Roadblocks to treating cognition sufficiently in MS Claire Riley |
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| 09:55-10:15 | Q & A, Discussion | ||
| 10:15-10:30 | Break |
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| 10:30-12:00 | SESSION - 11: Imaging developments in MS Discussants & Chairs: Nur Yüceyar, Mohammad Ali Sahraian, Serhat Okar |
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| 10:30-10:40 | Introduction to the session: Rethinking what we are measuring by imaging by MRI and PET in MS Serhat Okar |
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| 10:40-11:00 | From 2D to 3D understanding of MS lesion specificty Darin Okuda |
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| 11:00-11:20 | What is going on in the deep gray matter in MS Christina Azevedo |
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| 11:20-11:40 | What is going on in the normal appearing white matter in MS Cristina Granziera |
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| 11:40-12:00 | Q & A, Discussion | ||
| 12:00-13:00 | Lunch & In-Lunch Satellite Symposium - Merck Chair: Rana Karabudak |
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| Mavenclad in MS Treatment Refik Pul |
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| 13:00-14:45 | SESSION-12: Propensity for autoimmunity Discussants & Chairs: Hayrettin Tumani, Tania Kümpfel, Dicle Güç |
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| 13:00-13:15 | Introduction to the session: Common Risk Pathways in Autoimmunity Hayrettin Tumani |
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| 13:15-13:35 | A bioinformatics architecture of susceptibility to autoimmunity Mika Gustaffson |
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| 13:35-13:55 | Role of TCR as key to autoimmunity Batu Erman |
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| 13:55-14:15 | Autoimmune mechanisms of neurodegeneration
TBA |
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| 14:15-14:45 | Q & A, Discussion | ||
| 14:45-15:00 | Break |
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| 15:00-16:45 | SESSION-13: Don’t ignore the children Discussants & Chairs: Jacqueline Palace, Anne-Katrin Pröbstel, Sema Saltık |
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| 15:00-15:15 | Introduction to the session: From Childhood to Adulthood: Unraveling CNS Autoimmunity Across Ages Jacqueline Palace |
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| 15:15-15:35 | Why are CNS inflammatory disorders more aggressive in children Naila Makhani |
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| 15:35-15:55 | Autoimmune leukoencephalopathies in children Silvia Tenembaum |
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| 15:55-16:15 | Differences in children’s brain imaging compared to adults in MS Matilde Inglese |
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| 16:15-16:45 | Q & A, Discussion | ||
| 16:45-17:00 | Break |
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| 17:00-19:00 | SESSION - 14: Advances in MOG and NMO autoimmunity Discussants & Chairs: Kazuo Fujihara, Nasrin Asgari, Paulus Rommer |
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| 17:00-17:15 | Introduction to the session: Lessons From the Era of NMOSD as Distinct From MS at the Turn of the Millennium Kazuo Fujihara |
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| 17:15-17:35 | The Many Faces of MOG autoimmunity Romain Marignier |
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| 17:35-17:55 | Mechanism of action of MOG antibodies Orhan Aktaş |
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| 17:55-18:15 | What does MOG autoimmunity teach us about post-inflammatory CNS diseases? Axel Petzold |
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| 18:15-18:35 | The strange case of MOG- Why does it not progress like MS? Eoin Flanagan |
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| 18:35-19:00 | Q & A, Discussion | ||
| 19:00-20:00 | SESSION-15: Summary of the meeting Chairs: Serhan Sevim, Nilüfer Kale İçen Speakers: Serkan Özben, Mesude Tütüncü, Bilge Piri Çınar, Gülgün Uncu, Ahmet Kasım Kılıç |
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| 20:15 | Departure for Farewell Dinner | ||